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What is mesenchymal stem cell treatment for osteoarthritis? In early-phase clinical trials, intra-articular (IA) administration of MSCs leads to pain reduction and cartilage protection or healing. However, the consistent lack of engraftment indicates that the observed effect is delivered through a “hit-and-run” mechanism, by a temporal release of paracrine molecules. Can regenerative medicine help with osteoarthritis? One promise of regenerative medicine is cell-based treatments that can regrow cartilage, tendons and other tissues. This could provide relief for conditions like osteoarthritis, chronic tendonitis and degenerative disc disease in the spine. What is the newest treatment for osteoarthritis? A new treatment provides relief for people with osteoarthritis in the knee who are not ready, or not candidates, for knee replacement surgery. Knee embolization, also known as genicular or geniculate artery embolization, is a non-surgical procedure performed by an interventional radiologist.